Description

Ethyl 4-Bromo-7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-2-Carboxylate is a high-value, multi-functional synthetic building block designed for advanced organic synthesis. This compound is strategically engineered to serve as a key intermediate in the construction of complex molecules, particularly through cross-coupling reactions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and development pipelines.

Application

This versatile boronic ester derivative is a critical reagent in modern synthetic chemistry, enabling the efficient formation of carbon-carbon bonds. Its primary and related applications include:

• Suzuki-Miyaura Cross-Coupling Reactions: As a key electrophilic partner for constructing biaryl and heterobiaryl systems prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Synthesis of complex indole-based scaffolds for potential therapeutics in oncology, neurology, and virology.
• Agrochemical Research: Building block for novel herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Precursor for organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Used to create tagged molecules for studying biological pathways and protein interactions.
• Scale-up Process Chemistry: Suitable for kilogram-scale production under GMP conditions for late-stage clinical trial material.

Basic Information

Product Name	Ethyl 4-Bromo-7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-2-Carboxylate
CAS No.	2377609-01-1
Molecular Formula	C17H21BBrNO4
Molecular Weight	394.07 g/mol
Synonyms	4-Bromo-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylic acid ethyl ester; Ethyl 4-bromo-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate; 7-Boronic acid, 4-bromo-1H-indole-2-carboxylic acid ethyl ester, pinacol ester; 4-Bromo-7-pinacolatoboryl-1H-indole-2-carboxylic acid ethyl ester; Ethyl 4-bromo-7-(pinacolatoboryl)-1H-indole-2-carboxylate; CAS 2377609-01-1; BRN 2377609-01-1
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-2-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.