Description

3,5-Difluoropyridine-4-Boronic Acid Hydrate is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated pyridine-based drug candidates, including kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used to create novel fluorinated pyridine compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Ligand & Catalyst Development: Serves as a starting material for constructing sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), where fluorination tunes electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated boronic acids.

Basic Information

Item	Details
Product Name	3,5-Difluoropyridine-4-Boronic Acid Hydrate
CAS No.	2377606-43-2
Molecular Formula	C5H5BF2NO3 (anhydrous basis)
Molecular Weight	175.91 g/mol (anhydrous basis)
Synonyms	4-Borono-3,5-difluoropyridine Hydrate; (3,5-Difluoropyridin-4-yl)boronic Acid Hydrate; 3,5-Difluoropyridine-4-boronic Acid Pinacol Ester (precursor); 3,5-Difluoro-4-pyridineboronic Acid Hydrate; B-(3,5-Difluoro-4-pyridinyl)boronic Acid Hydrate; 4-Pyridineboronic acid, 3,5-difluoro-, hydrate; CAS 2377606-43-2
EINECS	Contact for details

Quality Control

Our 3,5-Difluoropyridine-4-Boronic Acid Hydrate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system supports compliance with global regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0% (anhydrous basis)
Water Content (KF)	≤10.0% (Hydrate form)
Heavy Metals (as Pb)	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.