Description

6-Chloro-5-Methyl-1-(Tetrahydro-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is a high-value, multi-functional indazole-based boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling building block. Its molecular architecture, featuring a protected indazole core and a pinacol boronate ester group, makes it indispensable for constructing complex heterocyclic scaffolds. This compound is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other biologically active small molecules.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronate ester functionality enables efficient carbon-carbon bond formation with aryl/heteroaryl halides for constructing complex molecular architectures.
• Agrochemical Research: Used in the discovery and development of new active ingredients for crop protection.
• Material Science: Serves as a precursor for organic electronic materials and functional polymers.
• Chemical Biology & Proteomics: Can be employed as a molecular probe or linker in bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring functionalized indazole derivatives.

Basic Information

Product Name	6-Chloro-5-Methyl-1-(Tetrahydro-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	2374152-83-5
Molecular Formula	C19H26BClN2O3
Molecular Weight	376.68 g/mol
Synonyms	6-Chloro-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1H-Indazole, 6-chloro-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-Chloro-5-methyl-1-(THP)-4-(pinacol boronate)-1H-indazole; 4-Borono-6-chloro-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole pinacol ester; 6-Chloro-5-methyl-1-(tetrahydropyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole; CAS 2374152-83-5
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Methyl-1-(Tetrahydro-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements for pharmaceutical development (GMP standards available upon request).

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided. Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.