Description

((2S,3S)-4-(tert-Butoxy)-3-(tert-Butyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Di-tert-Butylphosphine Oxide is a sophisticated chiral organophosphorus compound characterized by its unique benzo-fused oxaphosphole core. This compound is of significant value as a highly specialized ligand or catalyst precursor in advanced synthetic chemistry, enabling precise stereocontrol in challenging transformations. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Asymmetric Catalysis: Serving as a chiral ligand or precursor for transition metal catalysts in enantioselective synthesis, including hydrogenation, cross-coupling, and C-H activation reactions.
• Pharmaceutical Intermediate Synthesis: A key building block or directing agent in the multi-step synthesis of complex, stereochemically defined drug candidates.
• Organocatalysis: Potential application as an organocatalyst in Lewis base-catalyzed reactions due to its electron-rich phosphorus centers.
• Material Science Research: Investigation for incorporation into novel chiral polymers or frameworks with potential optical or electronic properties.
• Methodology Development: Used by academic and industrial research groups to develop new catalytic methodologies and explore reaction mechanisms.

Basic Information

Item	Detail
Product Name	((2S,3S)-4-(tert-Butoxy)-3-(tert-Butyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Di-tert-Butylphosphine Oxide
CAS No.	2374143-33-4
Molecular Formula	C25H44O3P2
Molecular Weight	454.57 g/mol
Synonyms	(2S,3S)-4-(tert-Butoxy)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl-di-tert-butylphosphine oxide; Di-tert-butyl-((2S,3S)-4-(tert-butoxy)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)phosphine oxide; Chiral benzooxaphosphole phosphine oxide; (S,S)-Benzoxaphosphole phosphine oxide ligand; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral chemical adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing specifications such as assay, chiral purity (ee), and impurity profiles. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is likely moisture-sensitive; handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.