Description

1H-Indazole, 4,6-Difluoro-1-(Tetrahydro-2H-Pyran-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized indazole core. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable indazole scaffold.
• Process Chemistry Development: Serves as a standard reference material for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• API Synthesis: Incorporated into the final molecular structure of potential therapeutics for oncology, inflammatory diseases, and central nervous system (CNS) disorders.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological mechanisms and target validation in cellular assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity building blocks.

Basic Information

Product Name	1H-Indazole, 4,6-Difluoro-1-(Tetrahydro-2H-Pyran-2-Yl)-
CAS No.	2368911-29-7
Molecular Formula	C12H12F2N2O
Molecular Weight	238.23 g/mol
Synonyms	4,6-Difluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 4,6-Difluoro-1-(tetrahydropyran-2-yl)-1H-indazole; 1-(Oxan-2-yl)-4,6-difluoro-1H-indazole; 1-(Tetrahydro-2H-pyran-2-yl)-4,6-difluoro-1H-indazole; 4,6-Difluoro-1-(2H-tetrahydropyran-2-yl)indazole; THP-protected 4,6-difluoroindazole; 4,6-Difluoroindazole THP ether; Advanced Indazole Building Block
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 4,6-Difluoro-1-(Tetrahydro-2H-Pyran-2-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the exacting standards required for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.