Description

5,6-Dichloro-1-[(2R)-Tetrahydro-2H-Pyran-2-Yl]-1 H-Indazol-4-Ol CAS NO 2368910-17-0 is a high-purity, chiral indazole derivative serving as a critical pharmaceutical intermediate and research chemical. Its value lies in its specific stereochemistry and functional groups, which make it a versatile building block for the synthesis of complex bioactive molecules. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Serves as a reference standard or a probe in enzymatic and cellular assays to study specific biological pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high purity and reliable supply.
• Custom Synthesis Building Block: Provided to contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds for clients.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	5,6-Dichloro-1-[(2R)-Tetrahydro-2H-Pyran-2-Yl]-1 H-Indazol-4-Ol
CAS No.	2368910-17-0
Molecular Formula	C₁₂H₁₂Cl₂N₂O₂
Molecular Weight	287.14 g/mol
Synonyms	5,6-Dichloro-1-[(2R)-tetrahydro-2H-pyran-2-yl]-1H-indazol-4-ol; (2R)-5,6-Dichloro-1-(oxan-2-yl)-1H-indazol-4-ol; 5,6-Dichloro-1-((2R)-tetrahydro-2H-pyran-2-yl)-1H-indazol-4-ol; 1H-Indazol-4-ol, 5,6-dichloro-1-[(2R)-tetrahydro-2H-pyran-2-yl]-; 2368910-17-0; (R)-5,6-Dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-ol; Chiral THP-protected dichloroindazolol
EINECS	Contact for details

Quality Control

Our 5,6-Dichloro-1-[(2R)-Tetrahydro-2H-Pyran-2-Yl]-1 H-Indazol-4-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data, including enantiomeric excess (ee), are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.