Description

4-Bromo-5-Chloro-6-Fluoro-1-(Tetrahydro-Pyran-2-Yl)-1H-Indazole is a high-purity, multi-halogenated indazole derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block in medicinal chemistry, enabling the synthesis of novel small-molecule drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for targeted drug discovery programs, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile halogenated indazole scaffold.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and route development for Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A foundational compound for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	4-Bromo-5-Chloro-6-Fluoro-1-(Tetrahydro-Pyran-2-Yl)-1H-Indazole
CAS No.	2368909-56-0
Molecular Formula	C12H11BrClFN2O
Molecular Weight	348.59 g/mol
Synonyms	4-Bromo-5-chloro-6-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1-(Oxan-2-yl)-4-bromo-5-chloro-6-fluoro-1H-indazole; 4-Bromo-5-chloro-6-fluoro-1-(tetrahydropyran-2-yl)-1H-indazole; THP-protected 4-Bromo-5-Chloro-6-Fluoroindazole; 2368909-56-0
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-5-Chloro-6-Fluoro-1-(Tetrahydro-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.