Description

5-Chloro-6-Fluoro-1-(Tetrahydro-Pyran-2-Yl)-1H-Indazol-4-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated indazole core protected by a tetrahydropyranyl (THP) group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule drugs, particularly for oncology and other disease areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Oncology Drug Development: Its indazole structure is valuable for creating kinase inhibitors and other targeted cancer therapies.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and cellular signaling processes.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Process Chemistry: Employed in route scouting and scale-up development for efficient API manufacturing.

Basic Information

Product Name	5-Chloro-6-Fluoro-1-(Tetrahydro-Pyran-2-Yl)-1H-Indazol-4-Ol
CAS No.	2368909-53-7
Molecular Formula	C₁₂H₁₂ClFN₂O₂
Molecular Weight	270.69 g/mol
Synonyms	5-Chloro-6-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-ol; 4-Indazolol, 5-chloro-6-fluoro-1-(tetrahydro-2H-pyran-2-yl)-; 1-(Oxan-2-yl)-5-chloro-6-fluoro-1H-indazol-4-ol; 5-Chloro-6-fluoro-1-(2-tetrahydropyranyl)-1H-indazol-4-ol; THP-protected 5-chloro-6-fluoro-1H-indazol-4-ol; CAS 2368909-53-7
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Fluoro-1-(Tetrahydro-Pyran-2-Yl)-1H-Indazol-4-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full analytical data are provided for each lot. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.