Description

5-Endo-Bcn-Pentanoic Acid is a high-purity, functionalized bicyclo[6.1.0]nonyne (BCN) derivative designed for advanced bioconjugation and materials science applications. Its core value lies in its exceptional reactivity in strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry, enabling rapid, catalyst-free, and bioorthogonal ligation under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and polymer chemistry who require reliable, high-quality building blocks for labeling biomolecules, creating hydrogels, and synthesizing novel materials.

Application

• Bioorthogonal Labeling and Imaging: Conjugation to azide-modified antibodies, proteins, or oligonucleotides for targeted cellular imaging and diagnostics via SPAAC.
• ADC (Antibody-Drug Conjugate) Development: Site-specific conjugation linker for attaching cytotoxic payloads to monoclonal antibodies, creating next-generation therapeutics.
• Proteomics and Biomolecule Functionalization: Modification of peptides, glycans, or other biomolecules to introduce probes, fluorophores, or affinity tags.
• Polymer and Materials Science: Key monomer or cross-linker for synthesizing functionalized polymers, smart hydrogels, and surface coatings with clickable handles.
• Chemical Biology Tool Development: Synthesis of activity-based probes (ABPs) and other chemical tools for studying enzyme function and metabolic pathways.
• Diagnostic Assay Development: Immobilization of capture molecules on biosensor surfaces or microarray platforms.

Basic Information

Product Name	5-Endo-Bcn-Pentanoic Acid
CAS No.	2364591-80-8
Molecular Formula	C14H20O2
Molecular Weight	220.31 g/mol
Synonyms	(1S,8S)-Bicyclo[6.1.0]non-4-yn-9-ylmethylpentanoic Acid; 5-endo-BCN-Pentanoic Acid; BCN-Pentanoic Acid; (1S,8S)-BCN-C5-COOH; 5-((1S,8S)-Bicyclo[6.1.0]non-4-yn-9-yl)pentanoic Acid; Bicyclo[6.1.0]nonyne-Pentanoic Acid; BCN Acid Linker; SPAAC Reagent BCN-C5-COOH
EINECS	Contact for details

Quality Control

Every batch of 5-Endo-Bcn-Pentanoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and performance consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment supports applications in GMP-compatible bioconjugation and research-grade chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.