Description

5-(Dimethylphosphoryl)Thiophene-2-Carboxylic Acid is a high-purity organophosphorus-thiophene hybrid building block of significant interest in advanced chemical synthesis. This compound matters for its unique structural motif, which combines electron-withdrawing phosphoryl and carboxylic acid functionalities on a thiophene scaffold, enabling precise molecular design. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in medicinal chemistry for kinase inhibitor research and as a precursor for functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, especially in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized phosphine-based ligands for transition metal catalysis.
• Functional Material Research: Employed in the development of organic electronic materials, such as semiconductors and conductive polymers, due to the thiophene backbone.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological processes involving phosphorylation and metal binding.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis services targeting complex, multi-functional molecules.

Basic Information

Product Name	5-(Dimethylphosphoryl)Thiophene-2-Carboxylic Acid
CAS No.	2361970-76-3
Molecular Formula	C8H9O4PS
Molecular Weight	232.19 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-(dimethylphosphinyl)-; 5-(Dimethylphosphinyl)-2-thiophenecarboxylic acid; 5-(Dimethylphosphoryl)thiophene-2-carboxylic acid; 5-(Dimethylphosphinyl)thiophene-2-carboxylic acid; Dimethyl(5-carboxy-2-thienyl)phosphine oxide; (5-Carboxy-2-thienyl)dimethylphosphine oxide
EINECS	Contact for details

Quality Control

Our 5-(Dimethylphosphoryl)Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.