Description

2-(2,6-Dioxopiperidin-3-Yl)-5-(Prop-2-Yn-1-Ylamino)Isoindoline-1,3-Dione is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold. This compound is of significant interest for its potential role in the development of novel therapeutic agents, particularly in targeted protein degradation and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• PROTAC (Proteolysis Targeting Chimera) Linker Synthesis: Serves as a critical building block for constructing bifunctional molecules designed to degrade specific disease-causing proteins.
• Cereblon (CRBN) E3 Ligase Ligand Development: Acts as a key component in molecules engineered to recruit the CRBN E3 ubiquitin ligase complex, a cornerstone of targeted protein degradation technology.
• Novel Immunomodulatory Drug (IMiD) Analogue Research: Used in the synthesis and evaluation of next-generation compounds with potential immunomodulatory and anti-cancer activities.
• Medicinal Chemistry & Lead Optimization: Provides a versatile chemical handle for structure-activity relationship (SAR) studies to improve drug potency, selectivity, and pharmacokinetic properties.
• Bioconjugation and Probe Development: The propynylamino group enables click chemistry reactions for labeling, imaging, or attaching payloads in chemical biology research.
• Preclinical Candidate Synthesis: Employed in the scale-up synthesis of promising drug candidates for in vivo efficacy and toxicology studies.

Basic Information

Product Name	2-(2,6-Dioxopiperidin-3-Yl)-5-(Prop-2-Yn-1-Ylamino)Isoindoline-1,3-Dione
CAS No.	2357110-24-6
Molecular Formula	C16H12N4O4
Molecular Weight	324.29 g/mol
Synonyms	5-(Prop-2-yn-1-ylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Thalidomide derivative with propynylamino substitution; CRBN ligand derivative; PROTAC linker precursor; IMiD-based chemical probe; 3-(5-(Prop-2-yn-1-ylamino)-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione; 2357110-24-6 (CAS Index Name)
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dioxopiperidin-3-Yl)-5-(Prop-2-Yn-1-Ylamino)Isoindoline-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.