Description

Methyl 5-Amino-1H-Indazole-3-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant chemical intermediate essential for modern drug discovery and development. This compound serves as a critical building block in the synthesis of complex heterocyclic molecules, particularly those targeting kinase inhibition and other therapeutic pathways. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions.
• Academic Research: Employed in university and institutional labs for novel synthetic methodology development and heterocyclic chemistry exploration.

Basic Information

Product Name	Methyl 5-Amino-1H-Indazole-3-Carboxylate Hydrochloride
CAS No.	2355385-26-9
Molecular Formula	C9H10N3O2 • HCl
Molecular Weight	229.65 g/mol (Free base: 193.20 g/mol)
Synonyms	5-Amino-1H-indazole-3-carboxylic acid methyl ester hydrochloride; Methyl 5-amino-1H-indazole-3-carboxylate HCl; 3-Carbomethoxy-5-aminoindazole hydrochloride; 5-Amino-3-methoxycarbonylindazole hydrochloride; 1H-Indazole-3-carboxylic acid, 5-amino-, methyl ester, hydrochloride; Methyl 5-aminoindazole-3-carboxylate hydrochloride; 2355385-26-9
EINECS	Contact for details

Quality Control

Our Methyl 5-Amino-1H-Indazole-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.