Description

(R)-3-(tert-Butyl)-4-(4',6'-Dimethoxy-[1,1':3',1''-Terphenyl]-5'-Yl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is a high-value, chiral organophosphorus compound with a complex, sterically hindered structure. This compound matters as a sophisticated chiral ligand or catalyst precursor, enabling asymmetric synthesis with high enantioselectivity in demanding chemical transformations. It is primarily needed by research and development chemists in the pharmaceutical and advanced materials sectors, where it serves as a critical building block for creating novel active pharmaceutical ingredients (APIs) and functional molecules. The CAS number for this product is 2351219-89-9.

Application

This specialized chiral phosphole derivative finds its primary utility in advanced synthetic chemistry, particularly in asymmetric catalysis. Its applications include:

• Asymmetric Catalysis: Serving as a chiral ligand for transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: A key precursor in the R&D and production of enantiomerically pure drug candidates and active pharmaceutical ingredients (APIs).
• Material Science Research: Used in the development of chiral organic electronic materials or as a component in sophisticated molecular architectures.
• Methodology Development: Employed by academic and industrial research groups to develop new catalytic systems and synthetic methodologies.
• Fine Chemical Production: Enabling the synthesis of other high-value, optically active fine chemicals and specialty compounds.

Basic Information

Product Name	(R)-3-(tert-Butyl)-4-(4',6'-Dimethoxy-[1,1':3',1''-Terphenyl]-5'-Yl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	2351219-89-9
Molecular Formula	C36H35O3P
Molecular Weight	546.64 g/mol
Synonyms	(R)-3-tert-Butyl-4-(4',6'-dimethoxy-[1,1':3',1''-terphenyl]-5'-yl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; (R)-DTB-DiMeO-Ph-Me-Ph-Me-BOP; Chiral Terphenyl-Substituted Phosphole Ligand; (R)-BOP Derivative; (R)-3-(tert-Butyl)-4-(4',6'-dimethoxyterphenyl-5'-yl)-2,3-dihydrobenzo[d][1,3]oxaphosphole
EINECS	Contact for details

Quality Control

Every batch of this high-purity chiral chemical is produced and analyzed under strict quality protocols. Certificates of Analysis (COA) are provided, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and identity confirmation (by NMR, IR, and MS). Our quality system ensures traceability and compliance with cGMP standards where applicable, meeting the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled with care, avoiding strong acids and organic solvents that may compromise its integrity. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.