Description

3-Isoquinolinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a sophisticated, high-purity Fmoc-protected amino acid derivative designed for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise molecular building blocks for the development of novel pharmaceuticals and bioactive peptides. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, biotechnology, and fine chemical industries for applications in solid-phase peptide synthesis (SPPS) and medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected unnatural amino acid building block for the controlled assembly of complex peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new therapeutic agents, particularly for creating analogs and probing structure-activity relationships (SAR).
• Bioconjugation: Acts as a specialized linker or intermediate for attaching peptides or other molecules to carriers, surfaces, or biomolecules.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening against biological targets.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality intermediate for the pilot and commercial-scale production of peptide-based active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Supports fundamental research in organic chemistry, biochemistry, and chemical biology.

Basic Information

Product Name	3-Isoquinolinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	2350614-77-4
Molecular Formula	C28H26N2O4
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-3-(2-isoquinolyl)-L-homoalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(isoquinolin-3-yl)butanoic acid; Fmoc-Homoisoquinolylalanine; Fmoc-3-isoquinolin-3-yl-L-homoalanine; Fmoc-3-(isoquinolin-3-yl)-L-homoalanine; N-α-Fmoc-3-(3-isoquinolyl)-L-homoalanine; Nα-Fmoc-3-(2-isoquinolyl)-L-homoalanine; Fmoc-3-(2-isoquinolyl)-DL-homoalanine (racemic mixture reference)
EINECS	Contact for details

Quality Control

Our 3-Isoquinolinebutanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.