Description

5-[(5-Aminobutyl)Amino]-2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione, CAS NO 2307476-95-3 is a high-purity, specialized chemical building block featuring a complex molecular architecture that combines isoindole-1,3-dione and piperidinyl-dione moieties. This compound is of significant value in advanced pharmaceutical research and development, particularly as a key intermediate for the synthesis of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteolysis-targeting chimera (PROTAC) development, and the discovery of new small-molecule drugs.

Application

This advanced chemical intermediate is designed for sophisticated research and manufacturing applications where precise molecular structure is critical.

• Pharmaceutical Intermediate: Serves as a core building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• PROTAC (Proteolysis-Targeting Chimera) Development: Used in the construction of heterobifunctional molecules designed for targeted protein degradation, a cutting-edge therapeutic modality.
• Medicinal Chemistry & Drug Discovery: Provides a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Bioconjugation & Linker Chemistry: The aminobutyl side chain offers a handle for conjugation to other molecules, peptides, or solid supports.
• Chemical Biology Research: Employed as a tool compound to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	5-[(5-Aminobutyl)Amino]-2-(2,6-Dioxo-3-Piperidinyl)-1H-Isoindole-1,3(2H)-Dione
CAS No.	2307476-95-3
Molecular Formula	C17H21N5O4
Molecular Weight	359.38 g/mol
Synonyms	5-[(5-Aminopentyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-Dioxo-3-piperidinyl)-5-[(5-aminopentyl)amino]-1H-isoindole-1,3(2H)-dione; Aminobutyl-Lenalidomide derivative; PROTAC linker intermediate; Thalidomide analog derivative; Cereblon-binding moiety derivative; E3 ligase ligand building block.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and consistency for every batch. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. Our commitment to cGMP (current Good Manufacturing Practice) principles and stringent quality management systems ensures reliable material for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.