Description

6-Methylspiro[Indoline-3,4'-Piperidin]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is of significant interest for its role as a key building block in modern medicinal chemistry, particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a key chiral building block in the production of complex, high-value active pharmaceutical ingredients.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and process development projects.
• Academic Research: Employed in university and institutional labs for studying spirocyclic compound chemistry and developing new synthetic methodologies.

Basic Information

Product Name	6-Methylspiro[Indoline-3,4'-Piperidin]-2-One Hydrochloride
CAS No.	2306264-96-8
Molecular Formula	C14H18N2O·HCl
Molecular Weight	266.77 g/mol
Synonyms	6-Methylspiro[indoline-3,4'-piperidin]-2-one HCl; 6-Methyl-2-oxospiro[indoline-3,4'-piperidine] hydrochloride; 6-Methyl-1'H-spiro[indoline-3,4'-piperidin]-2-one hydrochloride; 6-Methyl-2-oxo-1'H-spiro[indoline-3,4'-piperidine] hydrochloride; 6-Methylspiro[indoline-3,4'-piperidine]-2-one hydrochloride; 6-Methyl-2-oxospiro[indoline-3,4'-piperidine] hydrochloride salt; 6-Methyl-2-oxo-1'H-spiro[indoline-3,4'-piperidine] HCl
EINECS	Contact for details

Quality Control

Our 6-Methylspiro[Indoline-3,4'-Piperidin]-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.