Description

2-Oxa-5-Azabicyclo[2.2.2]Octane, Hydrochloride (1:1), (1R,4R)- is a high-purity, enantiomerically pure bicyclic amine hydrochloride salt, a valuable chiral building block in advanced organic synthesis. Its rigid, three-dimensional scaffold is prized for introducing specific stereochemistry and structural complexity into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced, stereospecific pesticides and herbicides where the specific (1R,4R) configuration is critical for bioactivity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study biological pathways and enzyme mechanisms.
• Advanced Material Research: Utilized as a monomer or additive in the synthesis of specialized polymers with unique structural properties.
• Custom Synthesis and Contract Manufacturing: A critical building block supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes.

Basic Information

Product Name	2-Oxa-5-Azabicyclo[2.2.2]Octane, Hydrochloride (1:1), (1R,4R)-
CAS No.	2306254-89-5
Molecular Formula	C6H12ClNO
Molecular Weight	149.62 g/mol
Synonyms	(1R,4R)-2-Oxa-5-azabicyclo[2.2.2]octane hydrochloride; (1R,4R)-Quinuclidin-3-one O-methyloxime hydrochloride (related precursor); endo-3-Aminoquinuclidine dihydrochloride derivative; Tropane analogue hydrochloride; Bicyclo[2.2.2]octane, 2-oxa-5-aza-, hydrochloride, (1R,4R)-; (1R,4R)-5-Azabicyclo[2.2.2]octan-2-ol hydrochloride; Chiral quinuclidine scaffold hydrochloride.
EINECS	Contact for details

Quality Control

Every batch of 2-Oxa-5-Azabicyclo[2.2.2]Octane Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity compliant with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.