Description

Methyl 6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-4-Carboxylate is a high-value, synthetically versatile boronic ester derivative of indole. This compound serves as a critical advanced pharmaceutical intermediate (API) and a key building block in modern organic synthesis, particularly for cross-coupling reactions. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting neurological and oncological pathways.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronate ester coupling partner for constructing biaryl and heterobiaryl structures central to many active molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science & OLED Development: Acts as a building block for creating organic semiconductors and light-emitting materials for electronic displays.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale clinical trial materials.

Basic Information

Product Name	Methyl 6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-4-Carboxylate
CAS No.	2304635-05-8
Molecular Formula	C16H22BNO4
Molecular Weight	303.17 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-4-carboxylic acid methyl ester; Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-4-carboxylate; 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-4-carboxylic Acid Methyl Ester; 1H-Indole-4-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 6-Boc-indole-4-carboxylate boronic ester (common name); Pinacol boronate ester of methyl 6-bromo-1H-indole-4-carboxylate (precursor-based name)
EINECS	Contact for details

Quality Control

Our Methyl 6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.