Description

{4-Fluoro-1-[Tris(Propan-2-Yl)Silyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Yl}Boronic Acid is a sophisticated, high-value organoboron building block featuring a fluorinated pyrrolopyridine core protected by a bulky tris(isopropyl)silyl (TIPS) group. This compound is specifically engineered for advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern pharmaceutical and agrochemical research. It is an essential intermediate for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex, fluorinated heterocyclic compounds in drug discovery and development, especially for targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functional group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for constructing drug-like molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic scaffolds for enhanced activity and stability.
• Material Science Precursor: Potential use in creating organic electronic materials and ligands for catalysis, leveraging its unique electronic properties from the fluorine atom and nitrogen-rich core.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the creation of molecular probes to study biological processes.

Basic Information

Product Name	{4-Fluoro-1-[Tris(Propan-2-Yl)Silyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Yl}Boronic Acid
CAS No.	2304634-59-9
Molecular Formula	C20H30BFN2O2Si
Molecular Weight	388.37 g/mol
Synonyms	4-Fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluoro-1-((triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid; (4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid; 1-TIPS-4-fluoro-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid; TIPS-Protected 4-fluoro-7-azaindole-5-boronic acid; CAS 2304634-59-9
EINECS	Contact for details

Quality Control

Our {4-Fluoro-1-[Tris(Propan-2-Yl)Silyl]-1H-Pyrrolo[2,3-B]Pyridin-5-Yl}Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.