Description

4-Bromo-2-(Dimethylphosphoryl)Benzonitrile is a high-value, multi-functional organophosphorus building block with a unique benzonitrile core. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), offering versatile reactivity for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning material properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and plant growth regulators, leveraging the phosphorus moiety for bioactivity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized phosphine-based ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science: Employed in the research and production of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized as a building block for designing molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Bromo-2-(Dimethylphosphoryl)Benzonitrile
CAS No.	2287315-21-1
Molecular Formula	C9H9BrNO3P
Molecular Weight	290.05 g/mol
Synonyms	2-(Dimethylphosphoryl)-4-bromobenzonitrile; 4-Bromo-2-(dimethylphosphoryl)benzonitrile; 4-Bromo-2-(dimethylphosphinyl)benzonitrile; Benzonitrile, 4-bromo-2-(dimethylphosphinyl)-; (4-Bromo-2-cyanophenyl)dimethylphosphine oxide; Dimethyl(4-bromo-2-cyanophenyl)phosphine oxide
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Dimethylphosphoryl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.