Description

(2-Fluorophenyl-3,4,5,6-D4)Boronic Acid CAS NO 2259315-50-7 is a deuterium-labeled derivative of 2-fluorophenylboronic acid, serving as a critical building block in advanced synthetic chemistry. Its primary value lies in enabling precise pharmacokinetic, metabolic, and mechanistic studies by acting as a stable, non-radioactive isotopic tracer. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating deuterated drug candidates and conducting mass spectrometry-based analytical work.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: A key precursor in the development of deuterium-labeled drugs, where deuterium incorporation can improve metabolic stability and pharmacokinetic profiles.
• Internal Standards for Mass Spectrometry: Used as a quantitative internal standard in LC-MS and GC-MS analysis for accurate bioanalysis and quantification of non-deuterated analogs in complex matrices.
• Mechanistic Reaction Studies: Employed in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to investigate reaction pathways and isotope effects.
• Metabolic Fate Tracing: Facilitates tracking of drug metabolites in in vitro and in vivo studies due to its isotopic label.
• Material Science Research: Used in the synthesis of novel deuterated organic electronic materials and ligands for catalysis.
• Contract Research & Development (CRO/CMO): Supplied to research organizations specializing in isotope chemistry and custom synthesis for client projects.

Basic Information

Item	Detail
Product Name	(2-Fluorophenyl-3,4,5,6-D4)Boronic Acid
CAS No.	2259315-50-7
Molecular Formula	C6D4HFBO2
Molecular Weight	143.94 g/mol (for D4 isotopologue)
Synonyms	2-Fluorophenyl-3,4,5,6-d4-boronic Acid; (2-Fluorophenyl-d4)boronic Acid; B-(2-Fluorophenyl-3,4,5,6-d4)boronic Acid; 2-Fluoro-d4-benzeneboronic Acid; (2-Fluorophenyl)boronic Acid-d4; 2-Fluorophenylboronic Acid-d4; 2-FBAd4; 2-Fluorobenzeneboronic Acid (phenyl-d4)
EINECS	Contact for details

Quality Control

Our (2-Fluorophenyl-3,4,5,6-D4)Boronic Acid is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by NMR and IR spectroscopy. We adhere to rigorous in-house standards designed for advanced synthetic and analytical use. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Keep the container tightly sealed in a desiccator to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.