Description

1H-Indole-2,3-Dione, 6-Bromo-4,7-Difluoro- is a high-purity, halogenated isatin derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise building blocks for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging its halogenated structure for enhanced bioactivity.
• Organic Synthesis Building Block: Employed in Suzuki, Sonogashira, and other cross-coupling reactions to introduce the indole-2,3-dione core with specific bromo and fluoro substituents.
• Material Science: Investigated as a monomer or functional component in the creation of organic semiconductors, dyes, and photoresponsive materials.
• Academic & Contract Research: Serves as a valuable reagent for methodological studies and library synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1H-Indole-2,3-Dione, 6-Bromo-4,7-Difluoro-
CAS No.	2250340-28-2
Molecular Formula	C8H2BrF2NO2
Molecular Weight	269.01 g/mol
Synonyms	6-Bromo-4,7-difluoro-1H-indole-2,3-dione; 6-Bromo-4,7-difluoroindoline-2,3-dione; 6-Bromo-4,7-difluoro-2,3-dihydro-1H-indole-2,3-dione; 4,7-Difluoro-6-bromoisatin; 6-Bromo-4,7-difluoroisatin; Br,4,7-diF-isatin; Isatin, 6-bromo-4,7-difluoro-
EINECS	Contact for details

Quality Control

Our 1H-Indole-2,3-Dione, 6-Bromo-4,7-Difluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.