Description

Mal-Peg5-Cootbu CAS NO 2250216-91-0 is a high-purity, functionalized polyethylene glycol (PEG) derivative, specifically a maleimide-terminated pentameric PEG linker. This compound is engineered to provide a reliable and efficient heterobifunctional cross-linking solution for bioconjugation and advanced material synthesis. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and diagnostics industries for creating stable, site-specific conjugates of peptides, proteins, and other biomolecules.

Application

• Bioconjugation Reagent: For site-specific coupling of thiol-containing biomolecules (e.g., antibodies, peptides, enzymes) to maleimide-reactive surfaces or other functional groups.
• ADC (Antibody-Drug Conjugate) Development: Serves as a critical linker component to attach cytotoxic payloads to monoclonal antibodies, enhancing therapeutic targeting and efficacy.
• PEGylation Chemistry: Used to introduce a hydrophilic PEG spacer, improving the solubility, stability, and pharmacokinetic profiles of therapeutic agents.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and chromatographic media with bioactive ligands for targeted applications.
• Hydrogel and Polymer Synthesis: Acts as a cross-linking agent in the development of biocompatible hydrogels for drug delivery and tissue engineering scaffolds.
• Diagnostic Assay Development: Facilitates the stable immobilization of capture antibodies or antigens on solid supports for ELISA and other immunoassay platforms.

Basic Information

Product Name	Mal-Peg5-Cootbu
CAS No.	2250216-91-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG5-C2-Boc; 3-Maleimidopropanoic acid, 3-[2-[2-[2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]ethoxy]ethoxy]ethoxy]propyl ester; Boc-NH-PEG5-MAL; t-Butyl (PEG5) maleimide; 1-Boc-amino-3,6,9,12,15-pentaoxaheptadecan-17-yl maleimide
EINECS	Contact for details

Quality Control

Our Mal-Peg5-Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.