Description

Ethyl 4-Bromo-5-Chloro-1H-Benzimidazole-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials due to its reactive halogen substituents and ester functionality. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzimidazole-based drug candidates, including potential kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Research: Serves as a versatile scaffold for developing new fungicides, herbicides, and plant growth regulators with enhanced efficacy.
• Material Science: Used in the research and development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Functions as a versatile building block for further derivatization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) or nucleophilic substitution, enabling rapid library expansion.
• Biochemical Probe Development: Employed in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Ethyl 4-Bromo-5-Chloro-1H-Benzimidazole-2-Carboxylate
CAS No.	2250023-38-0
Molecular Formula	C10H8BrClN2O2
Molecular Weight	303.54 g/mol
Synonyms	4-Bromo-5-chloro-1H-benzimidazole-2-carboxylic acid ethyl ester; Ethyl 4-bromo-5-chloro-1H-benzo[d]imidazole-2-carboxylate; 1H-Benzimidazole-2-carboxylic acid, 4-bromo-5-chloro-, ethyl ester; 4-Bromo-5-chloro-benzimidazole-1-carboxylic acid ethyl ester; 2250023-38-0; EC 000-000-0
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-5-Chloro-1H-Benzimidazole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.