Description

4-((6-Aminohexyl)Oxy)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hydrochloride is a high-purity, synthetic small molecule building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key intermediate for the synthesis of novel PROTACs (Proteolysis Targeting Chimeras) and other bifunctional molecules designed for targeted protein degradation. Research organizations and pharmaceutical companies engaged in oncology, neurodegenerative disease, and other therapeutic areas requiring precise protein modulation are the primary users of this material.

Application

• PROTAC (Proteolysis Targeting Chimeras) Linker Synthesis: Serves as a critical component for constructing the linker moiety that connects an E3 ligase ligand to a target protein binder.
• Bifunctional Degrader Development: Used as a core building block in the research and development of molecular glues and other heterobifunctional degraders.
• Chemical Biology Research: Enables the study of ubiquitin-proteasome system (UPS) pathways and intracellular protein turnover mechanisms.
• Oncology Drug Discovery: A key intermediate for creating novel therapeutics aimed at degrading disease-causing proteins in cancer cells.
• Neurological Disorder Research: Applied in the development of degraders targeting proteins implicated in neurodegenerative conditions.
• High-Value Pharmaceutical Intermediate: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of clinical candidates.

Basic Information

Product Name	4-((6-Aminohexyl)Oxy)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hydrochloride
CAS No.	2245697-88-3
Molecular Formula	C19H25ClN4O5
Molecular Weight	424.88 g/mol
Synonyms	4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride; 4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride; Thalidomide-PEG6-amine hydrochloride; Thalidomide-PEG6-NH2 HCl; Thalidomide-6-aminohexyloxy linker hydrochloride; E3 Ligase Ligand-Linker Conjugate; PROTAC Linker 6; (3-(4-((6-Aminohexyl)oxy)-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride)
EINECS	Contact for details

Quality Control

Our 4-((6-Aminohexyl)Oxy)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.