Description

(Pyridin-4-Yl-D4)Boronic Acid CAS NO 2241875-63-6 is a deuterated derivative of 4-pyridylboronic acid, where four hydrogen atoms are replaced with deuterium, serving as a crucial isotopically labeled building block in advanced chemical synthesis. This deuteration provides a stable isotopic label that is essential for mechanistic studies, metabolic research, and the development of novel compounds with modified physicochemical properties. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for applications requiring precise isotopic tracing and the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: A key precursor for incorporating deuterium into drug molecules to potentially improve metabolic stability, pharmacokinetic profiles, and reduce toxicity.
• Mechanistic & Metabolic Research: Used as a stable isotopic tracer in mass spectrometry and NMR studies to elucidate reaction pathways and drug metabolism.
• Suzuki-Miyaura Cross-Coupling Reactions: Functions as a deuterated boronic acid coupling partner for creating complex, labeled biaryl structures in medicinal chemistry.
• Agrochemical Intermediate: Employed in the research and development of novel, isotopically labeled pesticides and herbicides.
• Material Science Research: Used in the synthesis of deuterated organic semiconductors, ligands, and metal-organic frameworks (MOFs) for specialized analytical and electronic applications.
• Standards for Analytical Chemistry: Serves as an internal standard or reference material in quantitative LC-MS and GC-MS analysis for accurate quantification.

Basic Information

Product Name	(Pyridin-4-Yl-D4)Boronic Acid
CAS No.	2241875-63-6
Molecular Formula	C5D4H2BNO2
Molecular Weight	128.93 g/mol (for D4 isotopologue)
Synonyms	4-(D4)Pyridineboronic Acid; 4-Pyridylboronic Acid-d4; (4-Deuteriopyridin-4-yl)boronic Acid; (Pyridin-4-yl-d4)Boric Acid; 4-Boronopyridine-d4; 4-Pyridyl-D4-boronic Acid; B-(4-Pyridyl-D4)boronic Acid
EINECS	Contact for details

Quality Control

Our (Pyridin-4-Yl-D4)Boronic Acid is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, critical for research and development applications. Each batch is analyzed using advanced techniques including NMR (1H, 11B, 13C) and mass spectrometry to confirm deuteration level and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and allowed to reach room temperature before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Chemical Purity)
Isotopic Purity (D%)	≥98 atom % D
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.