Description

(2-(Methoxy-D3)Pyrimidin-5-Yl)Boronic Acid is a high-purity, deuterated boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling the synthesis of deuterium-labeled compounds, which are essential for advanced research in drug discovery and development. This compound is specifically designed for use by pharmaceutical researchers, agrochemical scientists, and material chemists working on deuterium isotope labeling, Suzuki-Miyaura cross-coupling reactions, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: A key precursor for synthesizing deuterium-labeled drug candidates to study metabolic pathways, improve pharmacokinetic profiles (PK/PD), and enhance drug stability.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, essential for constructing complex heterocyclic scaffolds found in many active molecules.
• Agrochemical Research & Development: Employed in the synthesis of novel, labeled agrochemicals for tracing environmental fate, metabolism in plants, and developing products with improved efficacy.
• Material Science & OLED Development: Serves as a building block for creating deuterated organic electronic materials, potentially enhancing the lifetime and performance of organic light-emitting diodes (OLEDs).
• Isotope Labeling for Analytical Standards: Used to prepare internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and other analytical techniques, ensuring accurate quantification in complex biological matrices.
• Medicinal Chemistry & Lead Optimization: Facilitates the exploration of structure-activity relationships (SAR) by introducing deuterium atoms at specific molecular sites to modulate biological activity.

Basic Information

Item	Detail
Product Name	(2-(Methoxy-D3)Pyrimidin-5-Yl)Boronic Acid
CAS No.	2241867-45-6
Molecular Formula	C5H4D3BN2O3
Molecular Weight	153.92 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(methoxy-d3)pyrimidine; (2-(Trideuteriomethoxy)pyrimidin-5-yl)boronic acid; 2-(Methoxy-d3)pyrimidine-5-boronic acid; Deuterated (2-Methoxypyrimidin-5-yl)boronic acid; 5-Borono-2-(methoxy-d3)pyrimidine; (2-(Methoxy-D3)-5-pyrimidinyl)boronic acid; B-[2-(Methoxy-d3)-5-pyrimidinyl]boronic acid
EINECS	Contact for details

Quality Control

Every batch of (2-(Methoxy-D3)Pyrimidin-5-Yl)Boronic Acid is manufactured and tested under strict quality management systems. We ensure high chemical purity and isotopic enrichment through advanced analytical techniques including NMR (1H, 11B, 13C) and HPLC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, assay, deuterium incorporation, and impurity profiles is provided with each shipment to guarantee consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.