Description

(2-(Methoxy-D3)Phenyl)Boronic Acid is a deuterated boronic acid derivative, a crucial building block in modern synthetic chemistry. Its core value lies in providing a stable, isotopically labeled phenylboronic acid moiety for Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of complex molecules with deuterium incorporation. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science who require precise isotopic labeling for metabolic studies, tracer applications, or to modify the physical properties of target molecules.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing deuterated drug candidates in medicinal chemistry, particularly for drugs targeting the central nervous system (CNS) or requiring improved metabolic stability.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed reactions to form carbon-carbon bonds, specifically for introducing a deuterated 2-methoxyphenyl group into complex organic frameworks.
• Metabolic Tracer Synthesis: Enables the creation of isotopically labeled compounds for use in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Agrochemical Research: Serves as a building block for developing novel, labeled pesticides or herbicides to study environmental fate and degradation pathways.
• Material Science: Used in the synthesis of deuterated organic semiconductors, liquid crystals, or polymers where isotopic substitution can fine-tune electronic or physical properties.
• Analytical Standard Development: Acts as a high-purity reference standard for mass spectrometry and NMR spectroscopy in analytical laboratories.

Basic Information

Product Name	(2-(Methoxy-D3)Phenyl)Boronic Acid
CAS No.	2241867-04-7
Molecular Formula	C7H6D3BO3
Molecular Weight	153.97 g/mol
Synonyms	(2-(Trideuteriomethoxy)phenyl)boronic acid; 2-(Methoxy-d3)benzeneboronic acid; (2-Methoxy-d3-phenyl)boronic acid; B-[2-(Methoxy-d3)phenyl]boronic acid; 2-(CD3O)C6H4B(OH)2; Deuterated 2-Methoxyphenylboronic Acid; (2-Methoxyphenyl-d3)boronic Acid
EINECS	Contact for details

Quality Control

Our (2-(Methoxy-D3)Phenyl)Boronic Acid is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is analyzed using advanced techniques including NMR (¹H, ¹¹B, ¹³C) and HPLC/MS to confirm structure, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing purity, assay, and isotopic purity are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and hydrolysis. The container should be kept in a well-ventilated area, away from heat and incompatible materials. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.