Description

1H-Indazole, 6-Fluoro-5-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a sophisticated boronic ester derivative of an indazole scaffold, designed as a key synthetic intermediate for advanced pharmaceutical research and development. This compound matters because it provides a highly functionalized, protected building block that enables efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are critical for constructing complex drug-like molecules. Pharmaceutical and biotechnology companies engaged in medicinal chemistry, particularly those developing kinase inhibitors and other small-molecule therapeutics, require this high-purity intermediate to accelerate their discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and CNS drug discovery programs.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Suzuki-Miyaura Cross-Coupling: The boronic ester functional group makes this compound an ideal partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl linkages.
• Kinase Inhibitor Development: The indazole core is a privileged structure in the design of potent and selective kinase inhibitors.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis organizations (CSOs) and CDMOs producing gram to kilogram quantities for clinical trial materials.
• Chemical Biology Probes: Can be utilized to create tool compounds for target validation and mechanistic studies in biological systems.

Basic Information

Product Name	1H-Indazole, 6-Fluoro-5-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2241720-68-1
Molecular Formula	C19H26BFN2O3
Molecular Weight	360.24 g/mol
Synonyms	6-Fluoro-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1-(THP)-6-Fluoro-5-methyl-1H-indazole-4-boronic acid pinacol ester; 6-Fluoro-5-methyl-1-THP-indazole-4-boronic acid pinacol ester; 1-THP-6-Fluoro-5-methyl-4-Bpin-indazole; CAS 2241720-68-1
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 6-Fluoro-5-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. All products undergo rigorous analytical testing including HPLC, NMR, and LC-MS to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.