Description

[3-Fluoro-1-(Hydroxymethyl)Cyclobutyl]Methanol is a versatile fluorinated cyclobutane derivative featuring dual hydroxymethyl functional groups, making it a valuable bifunctional building block for advanced organic synthesis. Its unique structure is critical for introducing the rigid, polar cyclobutyl motif into target molecules, which can significantly influence their physicochemical and biological properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorinated cyclobutane core can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands or organocatalysts, leveraging the stereogenic center for asymmetric synthesis applications.
• Material Science Monomer: Employed in the synthesis of specialty polymers and dendrimers, where its dual functionality allows for controlled polymerization and cross-linking.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution in alicyclic systems on molecular conformation and reactivity.
• Peptidomimetics and Bioisosteres: The fluorinated cyclobutyl group is used as a bioisostere for aromatic or other ring systems in the design of peptide mimics and protease inhibitors.

Basic Information

Product Name	[3-Fluoro-1-(Hydroxymethyl)Cyclobutyl]Methanol
CAS No.	2231673-56-4
Molecular Formula	C6H11FO2
Molecular Weight	134.15 g/mol
Synonyms	(3-Fluoro-1-(hydroxymethyl)cyclobutyl)methanol; 1,1-Bis(hydroxymethyl)-3-fluorocyclobutane; 3-Fluoro-1,1-bis(hydroxymethyl)cyclobutane; 3-Fluorocyclobutane-1,1-dimethanol; FCB-DM; Fluorocyclobutane dimethanol
EINECS	Contact for details

Quality Control

Our [3-Fluoro-1-(Hydroxymethyl)Cyclobutyl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development, ensuring reliable supply for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.