Description

n-Acetyl-L-Serine-2,3,3-D3 is a deuterium-labeled derivative of the amino acid serine, specifically designed for research and analytical applications. This compound matters as a critical stable isotope-labeled internal standard, enabling precise quantification and metabolic pathway tracing in mass spectrometry-based studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in proteomics, metabolomics, and pharmacokinetic research where high isotopic purity and chemical stability are paramount.

Application

• Mass Spectrometry Internal Standard: Used as a quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate measurement of L-serine and its metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Employed in deuterium-labeling studies to investigate serine metabolism, one-carbon unit transfer, and glycine synthesis in cell cultures and animal models.
• Proteomics & Biomarker Research: Facilitates the relative and absolute quantification of proteins and peptides in discovery-phase and targeted proteomic workflows.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a stable isotope-labeled analog for tracking the absorption, distribution, metabolism, and excretion (ADME) of serine-containing drug candidates.
• NMR Spectroscopy: Acts as a deuterated probe in nuclear magnetic resonance studies to elucidate molecular structure and dynamics without signal interference from protons.
• Quality Control & Method Development: Essential for developing and validating robust analytical methods in pharmaceutical quality control laboratories.

Basic Information

Product Name	n-Acetyl-L-Serine-2,3,3-D3
CAS No.	2230887-17-7
Molecular Formula	C5H6D3NO4
Molecular Weight	150.15 g/mol
Synonyms	N-Acetyl-L-serine-d3; (2S)-2-Acetamido-3-hydroxypropanoic-2,3,3-d3 acid; Acetylserine-d3; L-Serine, N-acetyl-, 2,3,3-d3; Deuterated N-Acetyl-L-serine; N-Acetyl-3-hydroxy-d3-alanine; Stable Isotope Labeled N-Acetylserine
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Serine-2,3,3-D3 is manufactured under strict quality systems to ensure the high isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.