Description

(S)-3,3'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogen Phosphate is a sophisticated chiral phosphoric acid derivative, a key class of organocatalysts enabling highly enantioselective transformations. This compound matters for its role as a high-performance asymmetric catalyst, crucial for synthesizing single-enantiomer intermediates in advanced pharmaceutical and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require exceptional stereocontrol in C-C and C-X bond-forming reactions.

Application

• Asymmetric Organocatalysis: Serving as a privileged Brønsted acid catalyst for enantioselective Friedel-Crafts alkylations, transfer hydrogenations, and Mannich reactions.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral active pharmaceutical ingredients (APIs) where high enantiomeric excess (ee) is mandated.
• Chiral Ligand Precursor: Used in the development and synthesis of novel chiral ligands for metal-catalyzed asymmetric processes.
• Methodology Development: A valuable tool for academic and industrial research groups exploring new asymmetric synthetic methodologies.
• Fine Chemical Production: Enabling the scalable, enantioselective synthesis of flavors, fragrances, and advanced material precursors.
• Agrochemical Synthesis: Applied in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	(S)-3,3'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogen Phosphate
CAS No.	2229836-07-9
Molecular Formula	C48H30F12O4P
Molecular Weight	945.70 g/mol
Synonyms	(S)-TRIP; (S)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate (H8 analog); (S)-H8-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; Octahydro-TRIP; (S)-H8-BINOL-derived phosphoric acid; Chiral phosphoric acid catalyst (H8 series); (S)-1,1'-Binaphthyl-2,2'-diyl hydrogen phosphate H8 derivative
EINECS	Contact for details

Quality Control

Every batch of our chiral catalyst is produced and analyzed under strict quality control protocols to ensure consistent high performance. We employ advanced analytical techniques including HPLC, NMR, and chiral analysis to verify chemical purity and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97%), chiral purity (ee >99%), and impurity profile is provided with each shipment, supporting cGMP and ISO 9001 compliant workflows for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to maintain optimal catalytic activity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.