Description

Benzenemethanol, 3-Bromo-2-Fluoro-α-Methyl-, (αs)- is a high-purity chiral building block and advanced pharmaceutical intermediate (API) of significant commercial interest. This compound is valued for its unique molecular architecture, which incorporates bromo, fluoro, and methyl substituents on a benzylic alcohol core, enabling precise modifications in complex synthetic pathways. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients, where its stereochemical purity is critical for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of new drug candidates, particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized aromatic polymers and liquid crystals with specific electronic or optical properties.
• Chemical Biology Probes: Utilized to create tagged molecules for studying enzyme mechanisms and protein interactions in biochemical research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Item	Detail
Product Name	Benzenemethanol, 3-Bromo-2-Fluoro-α-Methyl-, (αs)-
CAS No.	2227662-39-5
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	(αS)-3-Bromo-2-fluoro-α-methylbenzenemethanol; (S)-3-Bromo-2-fluoro-α-methylbenzyl alcohol; 1-(3-Bromo-2-fluorophenyl)ethan-1-ol (S-isomer); (S)-1-(3-Bromo-2-fluorophenyl)ethanol; Benzenemethanol, 3-bromo-2-fluoro-α-methyl-, (αS)-; (S)-3-Bromo-2-fluoro-α-methylbenzyl alcohol; 3-Bromo-2-fluoro-α-methyl-(S)-benzyl alcohol; Chiral bromo-fluoro benzyl alcohol intermediate
EINECS	Contact for details

Quality Control

Every batch of Benzenemethanol, 3-Bromo-2-Fluoro-α-Methyl-, (αs)- is produced under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, GC-MS, and NMR, to guarantee high enantiomeric excess (ee) and chemical purity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and chiral purity is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.