Description

trans-1-(tert-Butoxycarbonyl)-4-(2,4-Dimethoxyphenyl)Pyrrolidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolidine scaffold. This compound matters for its critical role as a sophisticated building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing novel therapeutics, where its specific stereochemistry and functional groups enable precise molecular construction.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in neurology and psychiatry.
• Protease Inhibitor Research: Used in the development of inhibitors for various protease enzymes, leveraging its carboxylic acid and protected amine functionalities.
• Peptidomimetic Chemistry: Serves as a constrained proline analog in the design and synthesis of peptidomimetics to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis to introduce defined three-dimensional complexity.
• Contract Development & Manufacturing (CDMO): Supplied to CDMOs for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	trans-1-(tert-Butoxycarbonyl)-4-(2,4-Dimethoxyphenyl)Pyrrolidine-3-Carboxylic Acid
CAS No.	2227659-66-5
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Boc-4-(2,4-Dimethoxyphenyl)pyrrolidine-3-carboxylic acid (trans); (3R,4S)-1-(tert-Butoxycarbonyl)-4-(2,4-dimethoxyphenyl)pyrrolidine-3-carboxylic acid; (3S,4R)-1-Boc-4-(2,4-dimethoxyphenyl)-3-pyrrolidinecarboxylic acid; trans-1-Boc-4-(2,4-dimethoxyphenyl)-3-pyrrolidinecarboxylic acid; 1-N-Boc-4-(2,4-dimethoxyphenyl)-3-pyrrolidinecarboxylic acid; Pyrrolidine-3-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-4-(2,4-dimethoxyphenyl)-, trans-; 2227659-66-5
EINECS	Contact for details

Quality Control

Our production of trans-1-(tert-Butoxycarbonyl)-4-(2,4-Dimethoxyphenyl)Pyrrolidine-3-Carboxylic Acid adheres to stringent quality systems suitable for pharmaceutical development. Every batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data (HPLC, NMR, MS) are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.