Description

(S)-3-(tert-Butyl)-4-(2,6-Dimethoxyphenyl)-2,2-Dimethyl-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is a high-value, chiral organophosphorus compound of significant interest in advanced synthetic chemistry. Its precise stereochemistry and unique heterocyclic structure make it a critical building block for the development of novel pharmaceuticals and specialty materials. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis, catalysis, and as a key intermediate in complex molecule construction.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Asymmetric Catalysis: Utilized as a ligand or catalyst component in stereoselective reactions to create single-enantiomer products with high optical purity.
• Agrochemical Research: Acts as a building block for developing novel, chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Investigated for the synthesis of advanced functional materials, including chiral polymers and liquid crystals.
• Academic & Process R&D: Employed in university and industrial laboratories for methodological development and scaling up innovative synthetic routes.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring complex, stereodefined intermediates.

Basic Information

Item	Detail
Product Name	(S)-3-(tert-Butyl)-4-(2,6-Dimethoxyphenyl)-2,2-Dimethyl-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	2227217-19-6
Molecular Formula	C22H29O3P
Molecular Weight	372.44 g/mol
Synonyms	(S)-3-tert-Butyl-4-(2,6-dimethoxyphenyl)-2,2-dimethyl-2,3-dihydrobenzo[d][1,3]oxaphosphole; (S)-DHBOP Derivative; Chiral Dihydrobenzooxaphosphole; (S)-Tert-Butyl Dimethoxy Dihydrobenzooxaphosphole; (S)-3-(tert-Butyl)-4-(2,6-dimethoxyphenyl)-2,2-dimethyl-2,3-dihydro-1,3-benzoxaphosphole; (S)-Benzoxaphosphole Intermediate; L-2227217-19-6; Phosphorus-containing Heterocycle
EINECS	Contact for details

Quality Control

Every batch of (S)-3-(tert-Butyl)-4-(2,6-Dimethoxyphenyl)-2,2-Dimethyl-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity, meeting the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere if prolonged storage is anticipated to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.