Description

3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Ol Hydrochloride is a high-value, structurally constrained bicyclic building block of significant interest in modern pharmaceutical and agrochemical research. Its unique [1.1.1]propellane-derived scaffold serves as a bioisostere for para-substituted benzene rings or tert-butyl groups, enabling the design of novel compounds with improved metabolic stability, solubility, and potency. This advanced intermediate is primarily sought by R&D chemists and process development scientists working on new active ingredients in life sciences.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry: Used in lead optimization and scaffold hopping to improve the physicochemical and pharmacokinetic properties of drug candidates.
• Agrochemical Research: Employed in the synthesis of new generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Chemical Biology: Serves as a versatile probe or linker in the synthesis of chemical tools for studying biological pathways and protein interactions.
• Material Science: Potential monomer or cross-linker for creating polymers with unique rigid, three-dimensional structures and properties.
• Academic & Contract Research: Essential for fundamental research in organic synthesis and methodology development involving strained bridgehead systems.

Basic Information

Product Name	3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Ol Hydrochloride
CAS No.	2227206-71-3
Molecular Formula	C7H14ClNO
Molecular Weight	163.65 g/mol
Synonyms	1-Aminomethyl-3-hydroxybicyclo[1.1.1]pentane hydrochloride; 3-(Aminomethyl)-1-hydroxybicyclo[1.1.1]pentane HCl; 3-Hydroxybicyclo[1.1.1]pentane-1-methanamine hydrochloride; [1.1.1]Propellane-3-methanol, 1-(aminomethyl)-, hydrochloride; Bicyclo[1.1.1]pentan-1-ol, 3-(aminomethyl)-, hydrochloride; 1-Aza-3-oxabicyclo[3.1.1]heptane hydrochloride (derivative); Aminomethylbicyclopentanol HCl
EINECS	Contact for details

Quality Control

Our 3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Ol Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive R&D and scale-up processes. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for full structural confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting identity, purity, and impurity profiles against customer-specific or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.