Description

1(2H)-Isoquinolinone, 4-Fluoro-6-(Trifluoromethyl)- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines an isoquinolinone scaffold with strategically placed fluorine and trifluoromethyl groups, enabling precise modulation of electronic and steric properties in target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery programs, particularly for targets requiring fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can improve lipophilicity and environmental persistence of the active compound.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as charge-transport layers or fluorophores, due to its electron-deficient aromatic system.
• Chemical Biology Probe Development: Utilized to create tagged or labeled molecules for studying biological pathways and protein-ligand interactions.
• Catalyst Ligand Synthesis: Potential precursor for developing novel ligands in transition metal catalysis, leveraging the nitrogen and oxygen donor atoms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector, enabling the production of bespoke compounds for client R&D.

Basic Information

Product Name	1(2H)-Isoquinolinone, 4-Fluoro-6-(Trifluoromethyl)-
CAS No.	2225879-23-0
Molecular Formula	C10H5F4NO
Molecular Weight	231.15 g/mol
Synonyms	4-Fluoro-6-(trifluoromethyl)-1(2H)-isoquinolinone; 4-Fluoro-6-(trifluoromethyl)isoquinolin-1(2H)-one; 6-(Trifluoromethyl)-4-fluoro-1,2-dihydroisoquinolin-1-one; 4-Fluoro-6-trifluoromethyl-1H-isoquinolin-1-one; FC-2367 (Potential Research Code); 4-F-6-CF3-Isoquinolinone; 1,2-Dihydro-4-fluoro-6-(trifluoromethyl)-1-isoquinolinone
EINECS	Contact for details

Quality Control

Every batch of 1(2H)-Isoquinolinone, 4-Fluoro-6-(Trifluoromethyl)- is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.