Description

Carbamic Acid, n-[(1R)-1-Methyl-2-[1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-4-Yl]Ethyl]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex chiral indazole core protected by a tetrahydropyranyl (THP) group. This compound matters as a critical building block in the synthesis of novel therapeutic agents, offering precise stereochemistry essential for biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of targeted small-molecule drugs, particularly in oncology and neurology.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates targeting specific enzymes or receptors.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high purity and reliable supply.
• Contract Manufacturing (CMO): A critical raw material for contract research and manufacturing organizations (CROs/CMOs) producing batches for clinical trials.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or ligand moiety of bifunctional PROTAC molecules for targeted protein degradation.

Basic Information

Product Name	Carbamic Acid, n-[(1R)-1-Methyl-2-[1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-4-Yl]Ethyl]-, 1,1-Dimethylethyl Ester
CAS No.	2222846-04-8
Molecular Formula	C21H31N3O3
Molecular Weight	373.49 g/mol
Synonyms	tert-Butyl N-[(1R)-1-methyl-2-[1-(oxan-2-yl)indazol-4-yl]ethyl]carbamate; (R)-tert-Butyl (1-methyl-2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)ethyl)carbamate; N-[(1R)-1-Methyl-2-[1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-4-Yl]Ethyl]Carbamic Acid 1,1-Dimethylethyl Ester; BOC-(R)-1-Me-2-(1-THP-indazol-4-yl)-ethylamine; (R)-1-(1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)propan-2-amine BOC-protected; CAS 2222846-04-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. Our quality management system supports production under GMP-like conditions suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.