Description

Elexacaftor CAS NO 2216712-66-0 is a high-purity, small-molecule pharmaceutical active ingredient. It is a critical component in the development of targeted therapies for cystic fibrosis, functioning as a CFTR modulator. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the formulation of next-generation treatments for respiratory diseases. We supply this material with a focus on stringent quality control and reliable global distribution.

Application

• Primary active pharmaceutical ingredient (API) in triple-combination therapies for cystic fibrosis.
• Key intermediate in advanced pharmaceutical research and development for CFTR protein correction.
• Reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical research tool for studying ion channel function and cellular transport mechanisms.
• Pre-clinical and clinical trial material for novel respiratory disease treatments.
• Formulation development for solid oral dosage forms such as tablets and granules.

Basic Information

Product Name	Elexacaftor
CAS No.	2216712-66-0
Molecular Formula	C26H27F3N2O6
Molecular Weight	520.50 g/mol
Synonyms	VX-445; ELX; N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-5-fluoro-2-[(2-fluorophenyl)methoxy]-4'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxamide; (R)-N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-5-fluoro-2-((2-fluorobenzyl)oxy)-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxamide; Elexacaftor (VX-445); Trikafta component (with tezacaftor and ivacaftor)
EINECS	Contact for details

Quality Control

Our Elexacaftor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing results for identity, purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.