Description

1H-Indole-2-Carboxamide, 1-[(1S,2S)-1-Cyano-2-Methylcyclopropyl]-n-Methyl-n-Phenyl-5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined molecular architecture. This compound is of critical importance for the research and development of novel therapeutic agents, particularly in the fields of oncology and neurology. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers seeking to develop next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Oncology Research: Used in the development of targeted cancer therapies, including kinase inhibitors and apoptosis inducers.
• Neurological Disorder Research: Applied in the discovery of compounds for treating conditions such as Alzheimer's disease, Parkinson's disease, and neuropathic pain.
• Chemical Biology: Acts as a molecular probe for studying enzyme function and protein-protein interactions in biological pathways.
• Process Chemistry Development: Utilized for scaling up synthetic routes and optimizing manufacturing processes for clinical trial material (CTM) production.
• Custom Synthesis: A starting point for the custom synthesis of complex analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	1H-Indole-2-Carboxamide, 1-[(1S,2S)-1-Cyano-2-Methylcyclopropyl]-n-Methyl-n-Phenyl-5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]-
CAS No.	2212021-81-1
Molecular Formula	C24H29N3O2
Molecular Weight	391.51 g/mol
Synonyms	(1S,2S)-1-Cyano-2-methylcyclopropyl 1-methyl-1-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indole-2-carboxylate; 1-[(1S,2S)-1-Cyano-2-methylcyclopropyl]-N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indole-2-carboxamide; Indole-2-carboxamide derivative CAS 2212021-81-1; Advanced Indole Pharmaceutical Intermediate; Stereospecific Indole Carboxamide
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carboxamide derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound may be hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.