Description

1H-Indole-2-Carboxamide, 1-(Cyanomethyl)-n-Methyl-n-Phenyl-5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]- is a sophisticated, high-value indole derivative with a complex stereochemistry, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where precise molecular architecture is paramount. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to accelerate the discovery and scalable production of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Organic Synthesis Building Block: Used in complex multi-step syntheses to construct intricate indole-based molecular frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Serves as a starting material for developing scalable, GMP-compliant manufacturing routes for APIs.
• Asymmetric Synthesis: Utilizes its defined stereocenter for the construction of other enantiomerically pure molecules.
• Contract Research & Manufacturing (CRAM): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	1H-Indole-2-Carboxamide, 1-(Cyanomethyl)-n-Methyl-n-Phenyl-5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]-
CAS No.	2212021-80-0
Molecular Formula	C24H27N3O2
Molecular Weight	389.49 g/mol
Synonyms	1-(Cyanomethyl)-N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indole-2-carboxamide; (4S)-1-(Cyanomethyl)-N-methyl-N-phenyl-5-(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, 1-(cyanomethyl)-N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-; CAS 2212021-80-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.