Description

1H-Indole-2-Carboxamide, n-Methyl-n-Phenyl-5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]- is a high-purity, advanced pharmaceutical intermediate characterized by its complex indole-based molecular scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic programs.
• CNS Drug Development: Serves as a core scaffold for compounds being investigated for neurological and psychiatric disorders.
• Oncology Research: Employed in the design and synthesis of potential kinase inhibitors and other anti-cancer agents.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.
• Academic Research: Utilized in university and institutional labs for chemical biology and pharmacology studies.

Basic Information

Product Name	1H-Indole-2-Carboxamide, n-Methyl-n-Phenyl-5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]-
CAS No.	2212021-79-7
Molecular Formula	C23H26N2O2
Molecular Weight	362.47 g/mol
Synonyms	N-Methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indole-2-carboxamide; (4S)-N-Methyl-N-phenyl-5-(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)-1H-indole-2-carboxamide; 5-[(4S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl]-N-methyl-N-phenyl-1H-indole-2-carboxamide; 2212021-79-7; UNII-7Q8I8L6Q3F; 7Q8I8L6Q3F; SCHEMBL24829031; AKOS040757896.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. All material is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods including HPLC, GC, and NMR. We operate in compliance with cGMP guidelines where applicable, and specifications can be tailored to meet the rigorous demands of preclinical and clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.