Description

4-(Bromomethyl)-1-{[2-(Trimethylsilyl)Ethoxy]Methyl}-1H-Indazole is a high-value, multi-functional synthetic building block designed for advanced organic synthesis. This compound is engineered to provide a reactive bromomethyl handle and a protected hydroxyl group via the SEM (2-(trimethylsilyl)ethoxymethyl) moiety, enabling precise and sequential functionalization. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel indazole-based drug candidates, particularly kinase inhibitors and anticancer agents.
• Agrochemical Research: Used in the development of new herbicides and pesticides where the indazole core imparts specific biological activity.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced organic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry due to its reactive bromomethyl group.
• Cross-Coupling Reactions: The bromomethyl group is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Nucleophilic Substitution: Facilitates the introduction of diverse nucleophiles (amines, thiols, alkoxides) to create a library of functionalized indazole derivatives.

Basic Information

Product Name	4-(Bromomethyl)-1-{[2-(Trimethylsilyl)Ethoxy]Methyl}-1H-Indazole
CAS No.	2173991-89-2
Molecular Formula	C14H21BrN2OSi
Molecular Weight	341.32 g/mol
Synonyms	4-(Bromomethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole; 1H-Indazole, 4-(bromomethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 4-Bromomethyl-1-SEM-indazole; 1-SEM-4-bromomethylindazole; 4-(Bromomethyl)-1-SEM-indazole; SEM-Protected 4-Bromomethylindazole; 2173991-89-2; 4-Bromomethyl-1-((2-(trimethylsilyl)ethoxy)methyl)indazole
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-1-{[2-(Trimethylsilyl)Ethoxy]Methyl}-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.