Description

6-Chloro-1,2-Dihydrospiro[Indole-3,3'-Pyrrolidin]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic indole structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, including potential candidates for central nervous system (CNS) and oncological targets.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially those targeting complex biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for the development of new active pharmaceutical ingredients (APIs).
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component in the design of heterobifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of specialized molecular tools for studying enzyme function and cellular processes.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	6-Chloro-1,2-Dihydrospiro[Indole-3,3'-Pyrrolidin]-2-One Hydrochloride
CAS No.	2173991-58-5
Molecular Formula	C12H12ClN2O • HCl
Molecular Weight	273.15 g/mol (Free base: 236.69 g/mol)
Synonyms	6-Chloro-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-2-one HCl; 6-Chloro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine] hydrochloride; 6-Chlorospiro[indole-3,3'-pyrrolidin]-2(1H)-one hydrochloride; Spiro[indole-3,3'-pyrrolidin]-2-one, 6-chloro-1,2-dihydro-, hydrochloride; 2173991-58-5; 6-Chloro-1,2-dihydro-2-oxospiro[indole-3,3'-pyrrolidine] hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Chloro-1,2-Dihydrospiro[Indole-3,3'-Pyrrolidin]-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.