Description

(3S,4R)-(4-Methyl-Pyrrolidin-3-Yl)-Carbamic Acid tert-Butyl Ester Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily needed by research institutions and pharmaceutical companies developing active pharmaceutical ingredients (APIs) and novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block for constructing complex, stereochemically defined molecular architectures in organic synthesis.
• Medicinal Chemistry Research: Serves as a precursor for creating focused libraries of compounds for biological screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for methodological development and the study of stereoselective reactions.

Basic Information

Product Name	(3S,4R)-(4-Methyl-Pyrrolidin-3-Yl)-Carbamic Acid tert-Butyl Ester Hydrochloride
CAS No.	2173637-29-9
Molecular Formula	C11H22N2O2 • HCl
Molecular Weight	250.77 g/mol (Free base: 214.30 g/mol)
Synonyms	tert-Butyl (3S,4R)-3-amino-4-methylpyrrolidine-1-carboxylate hydrochloride; (3S,4R)-1-Boc-3-amino-4-methylpyrrolidine hydrochloride; (3S,4R)-3-((tert-Butoxycarbonyl)amino)-4-methylpyrrolidine hydrochloride; 1-Boc-3-amino-4-methylpyrrolidine hydrochloride (stereoisomer); (3S,4R)-1-N-Boc-3-amino-4-methylpyrrolidine HCl; (3S,4R)-4-Methyl-3-((tert-butoxycarbonyl)amino)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer this intermediate in high-purity grades suitable for research and development under cGMP conditions where required. Every batch is characterized and tested to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing specific results for chiral purity, assay, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.