Description

(1R,3R)-1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(Dimethylglycyl)-2,3,4,9-Tetrahydro-1H-Pyrido [3,4-B]Indole-3-Carboxylate Methyl is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its complex molecular architecture, which serves as a critical building block in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly within the fields of neurology and oncology.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potential drug candidates targeting central nervous system disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of new chemical entities.
• Process Chemistry Development: Serves as a reference standard and starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Utilized in in vitro assays to investigate specific biological pathways and receptor interactions.
• Academic Research: Employed in university and institutional labs for advanced studies in organic synthesis and heterocyclic chemistry.
• Custom Synthesis: Basis for the preparation of labeled analogs (e.g., deuterated, C13) for pharmacokinetic and metabolic studies.

Basic Information

Product Name	(1R,3R)-1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(Dimethylglycyl)-2,3,4,9-Tetrahydro-1H-Pyrido [3,4-B]Indole-3-Carboxylate Methyl
CAS No.	2169996-11-4
Molecular Formula	C25H27N3O5
Molecular Weight	449.50 g/mol
Synonyms	(1R,3R)-Methyl 1-(1,3-benzodioxol-5-yl)-2-[(dimethylamino)acetyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate; (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-(dimethylamino)acetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester; Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-(dimethylamino)acetyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate; Tetrahydro-β-carboline derivative; Dimethylglycyl-THIQ derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles, ensuring compliance with the stringent requirements of pharmaceutical development. Our quality protocols are designed to support regulatory filings, with analytical methods typically including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry for definitive identification and quantification.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.