Description

1-(Bromomethyl)-3-Fluorobicyclo[1.1.1]Pentane is a high-value, multifunctional building block featuring the unique and highly sought-after bicyclo[1.1.1]pentane (BCP) scaffold. This compound is specifically engineered to serve as a critical intermediate in modern medicinal chemistry and advanced materials science, enabling the synthesis of novel molecules with improved metabolic stability and physicochemical properties. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing next-generation active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the rigid, three-dimensional BCP bioisostere into drug candidates, potentially improving potency, selectivity, and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the BCP core can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for creating advanced polymers and functional materials with unique structural and electronic properties.
• Medicinal Chemistry Tool Compound: Employed in fragment-based drug discovery and for probing structure-activity relationships (SAR) due to its distinct spatial geometry.
• Cross-Coupling Reactions: The bromomethyl group is reactive in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for carbon-carbon bond formation.
• Fluorine Chemistry: The fluorine atom allows for further derivatization and is valuable for tuning lipophilicity and membrane permeability in bioactive molecules.

Basic Information

Product Name	1-(Bromomethyl)-3-Fluorobicyclo[1.1.1]Pentane
CAS No.	2168405-39-6
Molecular Formula	C7H8BrF
Molecular Weight	191.04 g/mol
Synonyms	3-Fluoro-1-(bromomethyl)bicyclo[1.1.1]pentane; 1-(Bromomethyl)-3-fluorobicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane, 1-(bromomethyl)-3-fluoro-; 3-Fluoro-1-bromomethylbicyclo[1.1.1]pentane; 1-Bromomethyl-3-fluorobicyclo[1.1.1]pentane; 3-Fluoro-1-(bromomethyl)-1,3-diazabicyclo[1.1.1]pentane (incorrect but common search variant); BCP-Br-F building block
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-3-Fluorobicyclo[1.1.1]Pentane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the rigorous demands of research and scale-up. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and impurity profiles as determined by advanced analytical techniques. Our quality system is designed to support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the light-sensitive nature and reactive bromomethyl group, it is recommended to handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.