Description

Methanone, [5-(1-Aminoethyl)-2,3-Dihydro-1H-Indol-1-Yl](Tetrahydro-2H-Pyran-4-Yl)- CAS NO 2166617-06-5 is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture combining indoline and tetrahydropyran motifs. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in central nervous system (CNS) and oncology research. It is primarily sought after by pharmaceutical R&D laboratories and contract development and manufacturing organizations (CDMOs) engaged in innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting specific receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• API Development: Serves as a building block in the development route for new Active Pharmaceutical Ingredients (APIs), especially in neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Process Chemistry: Employed in route scouting and scale-up optimization for efficient and cost-effective manufacturing processes.
• Custom Synthesis: A starting material for the bespoke synthesis of complex molecules for client-specific research projects.

Basic Information

Product Name	Methanone, [5-(1-Aminoethyl)-2,3-Dihydro-1H-Indol-1-Yl](Tetrahydro-2H-Pyran-4-Yl)-
CAS No.	2166617-06-5
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	(Tetrahydro-2H-pyran-4-yl)[5-(1-aminoethyl)-2,3-dihydro-1H-indol-1-yl]methanone; 1-[5-(1-Aminoethyl)-2,3-dihydro-1H-indol-1-yl]-2-(tetrahydro-2H-pyran-4-yl)ethanone (tautomeric form); 2166617-06-5; 5-(1-Aminoethyl)-1-(tetrahydro-2H-pyran-4-ylcarbonyl)indoline; Advanced Indoline-THP Intermediate
EINECS	Contact for details

Quality Control

Every batch of this intermediate is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, supporting compliance with cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.