Description

{3-Phenylbicyclo[1.1.1]pentan-1-yl}methanol is a high-value, structurally constrained bicyclic building block featuring a phenyl-substituted [1.1.1]propellane core. This compound matters for its unique three-dimensional geometry and functional handle, which are critical for modulating the physicochemical properties of advanced materials and pharmaceuticals. It is primarily needed by medicinal chemists and material scientists in the pharmaceutical, agrochemical, and specialty polymer industries for applications in drug discovery and the synthesis of novel functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for creating molecules with improved metabolic stability and bioavailability.
• Medicinal Chemistry: Used as a bioisostere for para-substituted benzene rings or tert-butyl groups to explore novel chemical space and optimize drug-like properties in lead optimization campaigns.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that benefit from its rigid, three-dimensional scaffold.
• Material Science: Acts as a monomer or cross-linking agent for developing polymers and advanced materials with tailored mechanical and thermal properties.
• Chemical Biology: Utilized as a probe or linker in bioconjugation and the development of chemical tools for studying biological systems.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis research within R&D laboratories.

Basic Information

Item	Details
Product Name	{3-Phenylbicyclo[1.1.1]pentan-1-yl}methanol
CAS No.	2165347-55-5
Molecular Formula	C12H14O
Molecular Weight	174.24 g/mol
Synonyms	(3-Phenylbicyclo[1.1.1]pentan-1-yl)methanol; 1-(Hydroxymethyl)-3-phenylbicyclo[1.1.1]pentane; 3-Phenylbicyclo[1.1.1]pentane-1-methanol; Bicyclo[1.1.1]pentane-1-methanol, 3-phenyl-; [1.1.1]Propellane, 3-phenyl-1-methanol derivative
EINECS	Contact for details

Quality Control

Our {3-Phenylbicyclo[1.1.1]pentan-1-yl}methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.