Description

Isoquinoline, 4-Bromo-6-(Difluoromethyl)-7-(1-Methyl-1H-Pyrazol-4-Yl)- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active compounds. This heterocyclic building block is critical for medicinal chemistry research and development, enabling the creation of molecules with targeted biological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in oncology, CNS, and other therapeutic areas requiring complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Chemical Biology Probe Development: Serves as a core structure for developing tool compounds to study biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection products.
• Material Science: Exploration of applications in organic electronic materials due to its fused heterocyclic structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and biotech companies.

Basic Information

Product Name	Isoquinoline, 4-Bromo-6-(Difluoromethyl)-7-(1-Methyl-1H-Pyrazol-4-Yl)-
CAS No.	2158267-87-7
Molecular Formula	C14H10BrF2N3
Molecular Weight	338.15 g/mol
Synonyms	4-Bromo-6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)isoquinoline; 7-(1-Methyl-1H-pyrazol-4-yl)-4-bromo-6-(difluoromethyl)isoquinoline; 4-Bromo-6-difluoromethyl-7-(1-methylpyrazol-4-yl)isoquinoline; BRD-K4477; BRD K4477; BRDK4477; CAS 2158267-87-7
EINECS	Contact for details

Quality Control

Our Isoquinoline, 4-Bromo-6-(Difluoromethyl)-7-(1-Methyl-1H-Pyrazol-4-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for each lot. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and/or hygroscopic; handling under an inert atmosphere is recommended for long-term storage or after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.